Through yeast, frogs, and mice, scientists in the College of Natural Sciences may have found an inexpensive drug that shows promise as a chemotherapy for cancer.
Thiabendazole is an FDA-approved, generic drug taken orally that has been used for 40 years as an antifungal. It is not currently used for cancer therapy, but research by scientists in the College of Natural Sciences says could be.
Hye Ji Cha, Edward Marcotte, John Wallingford, and colleagues found that the drug destroys newly established blood vessels, making it a “vascular disrupting agent.” Inhibiting blood vessel growth can be an important chemotherapeutic tool because it starves tumors, which need new blood vessel formation to their out-of-control growth.
In trials using mice, the researchers found that thiabendazole decreased blood vessel growth in fibrosarcoma tumors by more than a half.
The drug also slowed tumor growth.
“This is very exciting to us, because in a way we stumbled into discovering the first human-approved vascular disrupting agent,” said Marcotte, professor of chemistry. “Our research suggests that thiabendazole could probably be used clinically in combination with other chemotherapies.”
The scientists’ discovery is a culmination of research that crosses both disciplines and organisms.
In a previous study, Marcotte and his colleagues found genes in single-celled yeast that are shared with vertebrates by virtue of their shared evolutionary history. In yeasts, which have no blood vessels, the genes are responsible for responding to various stresses to the cells. In vertebrates, the genes have been repurposed to regulate vein and artery growth, or angiogenesis.
“We reasoned that by analyzing this particular set of genes, we might be able to identify drugs that target the yeast pathway that also act as angiogenesis inhibitors suitable for chemotherapy,” said Marcotte.
They were right.
Cha, a graduate student in cell and molecular biology at the university, searched for a molecule that would inhibit the action of those yeast genes. She found that thiabendazole did the trick.
Cha then tested the drug in developing frog embryos. She found that frog embryos grown in water with the drug either didn’t grow blood vessels or grew blood vessels that were then dissolved away by the drug. Interestingly, when the drug was removed, the embryos’ blood vessels grew back.
Cha then tested the drug on human blood vessel cells growing in petri dishes, and found that the drug also inhibited their growth. Finally, she tested the drug on fibrosarcoma tumors in mice and found that it reduced blood vessel growth in the tumors as well as slowed the tumors’ growth.
“We didn’t set out to find a vascular disrupting agent, but that’s where we ended up,” said Wallingford, associate professor of developmental biology and Cha’s graduate advisor with Marcotte. “This is an exciting example of the power of curiosity-driven research and the insights that can come from blending disciplines in biology.”
The scientists’ goal is now to move the drug into clinical trials with humans. They are talking with clinical oncologists about next steps.
“We hope the clinical trials will be easier because it is already approved by the FDA for human use,” said Marcotte.
This piece was first published by Texas Science.
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